Cholinesterase inhibition and acetylcholine accumulation following intracerebral administration of paraoxon in rats
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منابع مشابه
Acetylcholine synthesis and release following continuous intracerebral administration of NGF in adult and aged Fischer-344 rats.
NGF promotes the survival and enhances the neurotransmitter phenotype of basal forebrain and striatal cholinergic neurons in brain of rat. The objective of the present study was to determine whether stimulations of the cholinergic neuronal markers ChAT and high-affinity choline uptake are reflected in enhanced synthesis and release of ACh. Enhancement of ACh release in brain of adult and aged r...
متن کاملStudies on cholinesterase; kinetics of the inhibition of acetylcholine esterase.
Enzyme inhibitors have long been used in the analysis of cellular function for separating different steps in complex chemical reactions and for studying the effect of blocking these reactions in the intact cell. Inhibitors of choline ester-splitting enzymes, especially the alkaloids prostigmine and eserine, have attracted the interest of investigators in view of the physiological rale of acetyl...
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Objective(s) Human umbilical cord blood (HUCB) is now considered as a valuable source for stem cell–based therapies. Previous studies showed that intravascular injection of the HUCB significantly improves neurological functional recovery in a rat model of intracerebral hemorrhage (ICH). In the present study, we hypothesize transplanted HUCB derived mononuclear cells (UC-MCs) can decrease injur...
متن کاملP-13: Histomorphometric Changes of The Skin in Rats Following Administration of Testosterone and Nettle
Testosterone is one of the important androgen. It has been reported that testosterone can have effects on hair follicles, dermal fibroblasts and interfollicular keratinocytes in vitro conditions. The purpose of this study is to investigate the effects of testosterone and nettle on skin structures and sebaceous glands. Materials and Methods: For this study, 20 healthy adult male wistar rats with...
متن کاملSerum cholinesterase: effect on the action of suxamethonium following administration to a patient with cholinesterase deficiency.
Purified serum cholinesterase 90 mg was administered to a patient with cholinesterase deficiency. The effect on the action of suxamethonium was studied. The half-life (44.7 h), time constant (64.5 h), rate constant (0.0155 h-1) and distribution volume (2740 ml) of the cholinesterase activity were determined.
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ژورنال
عنوان ژورنال: Toxicology and Applied Pharmacology
سال: 2009
ISSN: 0041-008X
DOI: 10.1016/j.taap.2009.02.022